Super B-Complex - High Absorption Methylated B Vitamins, Clean Label, Sustained Release - Complete Spectrum of B Vitamins with Folate, Boosted B12 & Vitamin C, 60 Tablets, by Igennus

Product Information

Allowitz KV, et al. (2022). Therapeutic potential of vitamin B1 derivative benfotiamine from diabetes to COVID-19.

Genetic test that evaluates MTHFR SNPs, as well as other methylation pathway genes such as MTR, MTRR, BHMT, and CBS Unfortunately, the system producing SAM-e relies on 5-MTHF, a critical B vitamin known as active or methyl folate, to be turned on. If there is enough 5-MTHF present, the methylation cycle will work effectively. Still, when the methylation switch is turned off and not creating enough SAM-e, numerous important molecules cannot be efficiently produced.

Testing and Treatment for Methylation Issues

The National Institutes of Health (NIH) recommends that adults consume 400 micrograms (mcg) of dietary folate equivalent (DFE) per day. People who are pregnant or nursing should consume 600 mcg DFE. Klean Athlete’s B-Complex stands out as a strong choice for athletes because it’s NSF Certified for Sport — a certification that ensures products are free of more than 280 substances banned by major athletics organizations.

Hu ML, Chen YK, Chen LC, Sano M. Para-aminobenzoic acid scavenges reactive oxygen species and protects DNA against UV and free radical damage. The Journal of Nutritional Biochemistry. 1995;6(9):504-508. One review of seven studies showed that both methylcobalamin and a B-complex containing cyanocobalamin were effective in reducing symptoms of diabetic neuropathy, a complication of diabetes that leads to nerve damage ( 15).Mahdavifar B, et al. (2021). Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey. Ebrahimi E, Khayati Motlagh S, Nemati S, Tavakoli Z. Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptoms. J Caring Sci. 2012;1(4):183-189. Published 2012 Nov 22. doi:10.5681/jcs.2012.026 In contrast, those who consumed a lot of folate were more likely to have increased methylation. These results support the idea that consuming certain nutrients affects DNA methylation. ElGendy K, et al. (2018). Effects of dietary interventions on DNA methylation in adult humans: systematic review and meta-analysis.

Vitamin B2. Also known as Riboflavin, it is required to convert folate to its active form, which is necessary for methylation. [17]

Non-Methylated Nutrients & Methylation

Volkov I, Rudoy I, Freud T, Sardal G, Naimer S, Peleg R, and Press Y. Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: A randomized, double-blind, placebo-controlled trial. The Journal of the American Board of Family Medicine. Jan 2009, 22(1) 9-16; doi:10.3122/jabfm.2009.01.080113 While the relationship between diet and DNA methylation needs more exploration, nutrition does seem to play a role. Fontecilla-Camps JC, Amara P, Cavazza C, Nicolet Y, Volbeda A (August 2009). "Structure-function relationships of anaerobic gas-processing metalloenzymes". Nature. 460 (7257): 814–822. Bibcode: 2009Natur.460..814F. doi: 10.1038/nature08299. PMID 19675641. S2CID 4421420. The process of DNA methylation partly relies on several nutrients. Evidence suggests that two nutrients may be particularly important: folate and vitamin B12. Methylated nutrients are your body’s “ methyl donors,” or nutrients that carry and transfer methyl groups from one compound to another. This process is called methylation,and it’s vital for the proper functioning of your body and overall health. (1)